Rubella

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Definition:
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 * Rubella**, commonly known as **German measles**, is a [|disease] caused by the[| rubella virus]. The name "rubella" is derived from Latin, meaning //little red//. Rubella is also known as German measles because the disease was first described by German physicians in the mid-eighteenth century. This disease is often mild and attacks often pass unnoticed. The disease can last one to three days. Children recover more quickly than adults. Infection of the mother by Rubella virus during pregnancy can be serious; if the mother is infected within the first 20 weeks of pregnancy, the child may be born with [|congenital rubella syndrome] (CRS), which entails a range of serious incurable illnesses. Spontaneous abortion occurs in up to 20% of cases.

After an incubation period of 14–21 days, German measles causes symptoms that are similar to the flu. The primary symptom of rubella virus infection is the appearance of a rash (exanthem) on the face which spreads to the trunk and limbs and usually fades after three days (that is why it is often referred to as three-day measles). The facial rash usually clears as it spreads to other parts of the body. Other symptoms include low grade fever, swollen glands (sub occipital & posterior cervical lymphadenopathy), joint pains, headache and conjunctivitis. The swollen [|glands] or [|lymph nodes] can persist for up to a week and the fever rarely rises above 38 oC (100.4 oF). The rash of German measles is typically pink or light red. The rash causes itching and often lasts for about three days. The rash disappears after a few days with no staining or peeling of the skin. When the rash clears up, the skin might shed in very small flakes where the rash covered it. Forchheimer's sign occurs in 20% of cases, and is characterized by small, red [|papules] on the area of the [|soft palate.] The disease is caused by Rubella virus, a togavirus that is enveloped and has a single-stranded RNA genome.[9home] The virus is transmitted by the respiratory route and replicates in the nasopharynx and lymph nodes. The virus is found in the blood 5 to 7 days after infection and spreads throughout the body. The virus has teratogenic properties and is capable of crossing the placenta and infecting the fetus where it stops cells from developing or destroys them.

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